Which part of the GI tract is primarily affected by Crohn's disease?

Crohn's disease is a type of inflammatory bowel disease that can affect any part of the gastrointestinal (GI) tract, but it most commonly affects the ileum, which is the last section of the small intestine. The ileum plays a crucial role in the absorption of nutrients, particularly vitamin B12 and bile acids. When Crohn's disease affects the ileum, it can lead to symptoms such as abdominal pain, diarrhea, fatigue, and nutrient deficiencies.

The prominence of ileal involvement is significant in clinical practice because complications such as strictures, fistulas, and malabsorption often arise in this region. Understanding that Crohn's disease frequently targets the ileum can help guide treatment and management strategies for those affected, including dietary modifications and medical therapies aimed at controlling inflammation and preventing complications.